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Fetuin-A

The first discovery of fetuin-A dates back to 1944 by K. Pedersen in the blood of a fetal calf (hence the name "fetuin") . Many years later, the independent studies by J.F. Heremans and K. Schmid with W. Burgi in 1960 and 1961, respectively, purified fetuin-A in humans, and hence it is now also known as α2-Heremans-Schmid glycoprotein (AHSG) in recognition of the discoverers. The comigration of fetuin-A with the α2-globulin fraction of plasma proteins during electrophoresis provides the prefix "α2" in its official name, AHSG .Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes. Fetuin-A binds with a plethora of receptors and exhibits multifaceted physiological and pathological functions. It is involved in the regulation of calcium metabolism, osteogenesis, and the insulin signaling pathway. It also acts as an ectopic calcification inhibitor, protease inhibitor, inflammatory mediator, anti-inflammatory partner, atherogenic factor, and adipogenic factor, among other several moonlighting functions. 

Product List

Validation Data

GMP Recombinant Human Fetuin A (Catalog: PCH90005)

Bioactivity image: The ED₅₀ for this effect is 50-200 μg/mL.

GMP Recombinant Bovine Fetuin A (Catalog: PCB90006)

Bioactivity image: The ED₅₀ for this effect is ≤100 μg/mL.

References

1. The structure, biosynthesis, and biological roles of fetuin-A: A review. Chekol Abebe E, et al. Front Cell Dev Biol. 2022. [PMID: 35923855]

2. Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin. Lin YH,et al. J Proteome Res. 2018. [PMID: 29966421]

3. Fetuin-A regulation of calcified matrix metabolism. Jahnen-Dechent W, et al. Circ Res. 2011. [PMID: 21659653]