Lung Cancer
Lung Cancer, also known as lung carcinoma, is a malignant tumor that originates in the lung tissue. It is typically caused by genetic damage to the DNA of airway cells, often due to smoking or inhalation of harmful chemicals.
NSCLC
Non-Small-Cell Lung Cancer accounts for approximately 80% to 85% of all lung cancer cases.
SCLC
Small-Cell Lung Cancer accounts for about 10% to 15% of lung cancer cases.
The occurrence and development of lung cancer are closely related to the abnormal activation or inhibition of various signaling pathways. An in-depth understanding of the molecular mechanisms of these signaling pathways is of great significance for the early diagnosis, molecular typing, and targeted treatment of lung cancer.
Signaling Pathways in Lung Cancer
The Wnt/β-catenin signaling pathway plays a significant role in the occurrence, progression, metastasis, and drug resistance of lung cancer. Its abnormal activation is closely related to the invasiveness, stem cell characteristics, and drug resistance of lung cancer.
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| β-catenin | AMRe03762 | beta Catenin Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| APC | AMRe02900 | APC Rabbit Monoclonal Antibody | WB,IHC,ICC/IF,IP | Human |
| c-Myc | AMRe21557 | c-Myc Rabbit Monoclonal antibody | WB,IHC,IF,IP,ELISA | Human,Mouse,Rat |
| Cyclin D1 | AMRe09589 | Cyclin D1 (10Z18) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,IP,IF-P | Human,Mouse,Rat |
| LEF1 | AMRe02209 | LEF1 Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| TCF3 | AMRe83733 | TCF3 Rabbit Monoclonal Antibody | WB,FC | Human |
| TCF4 | AMRe18735 | TCF4 (14L3) Rabbit Monoclonal Antibody | WB,IHC-P,FC,IF-P | Human,Mouse |
| Wnt1 | AMM80766 | WNT1 Mouse Monoclonal Antibody | WB,IHC,ICC,FC,ELISA | Human,Mouse |
| Wnt2 | AMRe83732 | WNT2 Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
| Wnt2b | AMRe02774 | Wnt2b Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| Wnt3 | AMM03546 | Wnt3 (4F11) Mouse Monoclonal Antibody | WB | Transfected |
| Wnt5a | AMRe02775 | Wnt5a Rabbit Monoclonal Antibody | WB,ICC/IF | Human |
| Wnt5b | AMRe19923 | Wnt5b (8N15) Rabbit Monoclonal Antibody | WB,FC | Human |
| Wnt10b | AMM80777 | WNT10B Mouse Monoclonal Antibody | WB,IHC,ICC,ELISA | Human |
| Wnt16 | AMRe02773 | Wnt16 Rabbit Monoclonal Antibody | WB,IP | Human,Mouse,Rat |
| Frizzled-1 | APRab11139 | Frizzled-1 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Rat,Mouse,Rice |
| Frizzled-2 | APRab11141 | Frizzled-2 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| Frizzled-3 | APRab11142 | Frizzled-3 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse |
| Frizzled-4 | APRab11143 | Frizzled-4 Rabbit Polyclonal Antibody | IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| Frizzled-5 | APRab11145 | Frizzled-5 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| Frizzled-6 | APRab11147 | Frizzled-6 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse |
| Frizzled-7 | APRab11148 | Frizzled-7 Rabbit Polyclonal Antibody | WB,FC,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse |
| Frizzled-8 | AMRe11137 | Frizzled 8 (11I2) Rabbit Monoclonal Antibody | WB,IHC-P | Human,Mouse,Rat |
| Frizzled-9 | AMRe11138 | Frizzled 9 / CD349 (15O7) Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
| Frizzled-10 | APRab11140 | Frizzled-10 Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Monkey |
| Frizzled-5/8 | APRab11146 | Frizzled-5/8 Rabbit Polyclonal Antibody | WB,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| LRP5 | AMRe86485 | LRP5 Rabbit Monoclonal Antibody | WB, IP | Human,Mouse,Rat |
| LRP6 | AMRe13436 | LRP6 (5A10) Rabbit Monoclonal Antibody | WB | Human,Mouse |
| GSK-3β | AMRe03750 | GSK3 beta Rabbit Monoclonal Antibody | WB,IHC-P | Human,Rat,Hamster |
| Axin1 | AMM81858 | AXIN1 Mouse Monoclonal Antibody | ICC,FC,ELISA | Human |
| Axin2 | AMRe01704 | Axin 2 Rabbit Monoclonal Antibody | WB | Human,Mouse,Rat |
The mutation of the KRAS gene is the most common oncogenic gene mutation in lung cancer, affecting cell proliferation, differentiation, and survival.
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| KRAS | APRab13128 | K-Ras Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
The PI3K/Akt signaling pathway plays a crucial role in lung cancer, and its abnormal activation is closely related to the proliferation of tumor cells, drug resistance, angiogenesis, and immune evasion.
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| PI3K p85α | APRab16101 | PI 3-kinase p85α Rabbit Polyclonal Antibody | WB,IHC-P,IF-P,IF-F,ICC/IF,ELISA | Human,Mouse,Rat |
| AKT | AMRe01622 | AKT Rabbit Monoclonal Antibody | WB,ICC/IF | Human,Mouse,Rat |
| mTOR | AMRe05951 | Phospho-mTOR (S2481) (4Y3) Rabbit Monoclonal Antibody | WB,IHC-P,IF-P | Human,Mouse |
The abnormal activation of this pathway is associated with the proliferation and survival of tumor cells.
| Target | Catalog# | Product Name | Reactivity | Application |
|---|---|---|---|---|
| Shh | AMM81142 | SHH Mouse Monoclonal Antibody | WB,IHC,FC,ELISA | Human,Mouse,Monkey |
| PTCH1 | APRab00420 | PTCH1 Rabbit Polyclonal Antibody | WB,IHC-P,ELISA | Human,Mouse |
| Smoothened | AMRe86750 | Smoothelin Rabbit Monoclonal Antibody | WB, IHC-P | Human,Mouse,Rat |
| GLI1 | AMRe11461 | Gli1 (17P5) Rabbit Monoclonal Antibody | WB | Human |
| GLI2 | AMM83347 | GLI2 Mouse Monoclonal Antibody | IHC | Human |
| GLI3 | AMRe11464 | Gli3 (10W4) Rabbit Monoclonal Antibody | WB,IHC-P,ICC/IF,IF-P | Human |
| SUFU | AMRe86597 | SUFU Rabbit Monoclonal Antibody | WB, FC | Human,Mouse,Rat |
References
- Xue C, Chu Q, Shi Q, et al. Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances. Signal Transduct Target Ther. 2025 Apr 4;10(1):106.
- Azzolin L, Panciera T, Soligo S,et al. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell. 2014 Jul 3;158(1):157-70.
- Sarapultsev A, Gusev E, Komelkova M, et al.. JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. Mol Biomed. 2023 Nov 8;4(1):40.
- Xue C, Yao Q, Gu X,et al. Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer. Signal Transduct Target Ther. 2023 May 19;8(1):204.
- Stabile H, Scarno G, Fionda C, et al. JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians. Immunol Rev. 2018 Nov;286(1):148-159.
- Cao X, Khitun A, Luo Y, et al. Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24. Nat Commun. 2021 Jan 21;12(1):508.
- Nepstad I, Hatfield KJ, Grønningsæter IS, Reikvam H. The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells. Int J Mol Sci. 2020 Apr 21;21(8):2907.
- Yi J, Zhu J, Wu J, et al. Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31189-31197.
- M. Nacif, O. Shaker. Targeting Transforming Growth Factor-β (TGF-β) in Cancer and Non-Neoplastic Diseases. Journal of Cancer Therapy. 2014, 5, 735-747
- Zhang Y, Lu WJ, Bulkley DP,et al. Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28838-28846.
- Song H, Zhang Y. Regulation of pancreatic stellate cell activation by Notch3. BMC Cancer. 2018 Jan 5;18(1):36.
- Guo Q, Jin Y, Chen X, et al. NF-κB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther. 2024 Mar 4;9(1):53.
- Hayden MS, Ghosh S. NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 2022 Feb 1;26(3):203-34.
 | Voisey Voisey is a technical support specialist at EnkiLife, proficient in immunology and cell biology. She is committed to providing customers with professional and efficient technical support. Additionally, she is involved in research on customers' fields of study and designs highly cost-effective solutions for them. |