SOX12_MOUSE Q04890
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UniProt:Q04890
Recommended name：Transcription factor SOX-12
EC number：
Alternative names：
Cleaved into：
GeneID：20667
Gene names (primary )：Sox12
Gene names (synonym )：Sox-12
Gene names (ORF )：
Length：314
Mass：34083
Sequence：MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRSSSIADLVFTY
Tissue specificity：Expressed in splenic and thymic regulatory T-cells (at protein level) (PubMed:30190287). Expressed in embryonic molar and incisor teeth (PubMed:8921394). {ECO:0000269|PubMed:30190287, ECO:0000269|PubMed:8921394}.
Induction：Induced by T-cell receptor signaling in naive CD4-positive T-cells and in splenic and thymic regulatory T-cells (PubMed:30190287). Up-regulated in splenic T reg cells by dextran sulfate sodium (DSS)-induced colitis (PubMed:30190287). {ECO:0000269|PubMed:30190287}.
Developmental stage：Widely expressed in the developing embryo from 9.5 dpc to 12.5 dpc (PubMed:8441686, PubMed:18505825, PubMed:18403418, PubMed:20596238). Expressed throughout the central and peripheral nervous system, as well as the mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc (PubMed:18403418). Strongly expressed in the lens of the eye, developing cerebral cortex, the dorsal cortical plate, thalamus, hippocampus and cerebellar cortex in the brain at 14.5 dpc (PubMed:18505825). Expressed in skin, spinal cord, lung, liver, intestine, kidney, heart, muscle, cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Abundantly expressed in the brain, heart and lung, with low expression in the liver, pancreas, and small intestine at postnatal day 2 (PubMed:18403418). {ECO:0000269|PubMed:18403418, ECO:0000269|PubMed:18505825, ECO:0000269|PubMed:20596238, ECO:0000269|PubMed:8441686}.
Protein families：