Interleukins (ILs)
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells.
Many interleukins are classified into families based on structural similarities, receptor chain usage, and functional properties. Examples include the IL-1 family, IL-2 family, IL-6 family, IL-10 family, IL-12 family, IL-17 family, and others. Each family has unique characteristics and plays specific roles in immune regulation and inflammation.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| IL-2 | PCH90024 | Recombinant Human IL-2 | Human | 15.4 kDa |
| IL-3 | PCH90028 | Recombinant Human IL-3 | Human | 15 kDa |
| IL-4 | PCH90029 | Recombinant Human IL-4 | Human | 15 kDa |
| IL-6 | PCH90030 | GMP Recombinant Human IL-6 | Human | 20.8 kDa |
| IL-7 | PCH90031 | GMP Recombinant Human IL-7 | Human | 17.3 kDa |
| IL-12 | PCH90020 | GMP Recombinant Human IL-12 | Human | 59 kDa |
| IL-13 | PCH90021 | GMP Recombinant Human IL-13 | Human | 12.3 kDa |
| IL-15 | PCH90022 | GMP Recombinant Human IL-15 | Human | 12.7 kDa |
| IL-18 | PCH90023 | GMP Recombinant Human IL-18 | Human | 18.2 kDa |
| IL-21 | PCH90025 | GMP Recombinant Human IL-21 | Human | 15.9 kDa |
| IL-21(hFc Tag) | PCH90055 | GMP Recombinant Human IL-21(hFc Tag) | Human | 51 kDa |
| IL-23 | PCH90026 | GMP Recombinant Human IL-23 | Human | 55.0 kDa(IL-23singlechain); 36.5 kDa(p40)&18.5 kDa(p19) |
| OSM | PCH90036 | GMP Recombinant Human OSM | Human | 22 kDa |
Validation Data
GMP Recombinant Human IL-2 (Catalog: PCH90024)
IL-2 SDS-PAGE image
Bioactivity image: ≥1×107 IU/mg. Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells.GMP Recombinant Human IL-4 (Catalog: PCH90029)
IL-4 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤ 0.2 ng/mL.GMP Recombinant Human IL-6 (Catalog: PCH90030)
IL-6 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤ 0.2 ng/mL.GMP Recombinant Human IL-7 (Catalog: PCH90031)
IL-7 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤30ng/ml.GMP Recombinant Human IL-12 (Catalog: PCH90020)
IL-12 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ＜0.5 ng/mL.GMP Recombinant Human IL-13 (Catalog: PCH90021)
IL-13 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤1.0ng/ml, corresponding to a specific activity of ≥1×106 U/mg.GMP Recombinant Human IL-15 (Catalog: PCH90022)
IL-15 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤0.5ng/ml.GMP Recombinant Human IL-18 (Catalog: PCH90023)
IL-18 SDS-PAGE image
Bioactivity image: The ED50 for this effect is 1.5-9 ng/mL.GMP Recombinant Human IL-21 (Catalog: PCH90025)
IL-21 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤ 8 ng/mL.GMP Recombinant Human OSM (Catalog: PCH90036)
OSM SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤ 2 ng/mL.GMP Recombinant Human IL-3 (Catalog: PCH90028) GMP Recombinant Human IL-23 (Catalog: PCH90026)
IL-3 SDS-PAGE image
IL-23 SDS-PAGE image
GMP Recombinant Human IL-21(hFc Tag) (Catalog: PCH90055)
IL-21(hFc Tag) SDS-PAGE image
References
1.Evolutionary divergence and functions of the human interleukin (IL) gene family. Brocker C, et al. Hum Genomics. 2010. [PMID: 21106488]
2.Implication of Interleukin Family in Cancer Pathogenesis and Treatment. Gonzalez-Aparicio M, et al. Cancers (Basel). 2021. [PMID: 33804410]
3.The history of fever, leukocytic pyrogen and interleukin-1. Dinarello CA. Temperature (Austin). 2015. [PMID: 27226996]
4.Analytic review: Interleukin-6 in surgery, trauma, and critical care: part I: basic science. Jawa RS, et al. J Intensive Care Med. 2011. [PMID: 21262749]
5.Interleukins as Mediators of the Tumor Cell-Bone Cell Crosstalk during the Initiation of Breast Cancer Bone Metastasis. Haider MT, et al. Int J Mol Sci. 2021. [PMID: 33809315]
6. Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network. Huang M, et al. Pharmaceuticals (Basel). 2024. [PMID: 38256942]
7. Interleukin-17 family members in health and disease. Chung S H, et al. International immunology. 2021. [PMID: 34611705]
8. The immunobiology of the interleukin-12 family: room for discovery. Wojno E D T, et al. Immunity. 2019. [PMID: 30995503]
9. Interleukin-6 family cytokines. Rose-John S. Cold Spring Harbor perspectives in biology. 2018.
10. Inflammasome-independent regulation of IL-1-family cytokines. Netea M G, et al. Annual review of immunology. [PMID: 25493334]
11. Structural analysis of cytokines comprising the IL-10 family. Zdanov A. Cytokine & growth factor reviews. 2010. [PMID: 20846897]
12. Interleukin-2 family cytokines: potential for therapeutic immmunoregulation. Dumont F J. Expert Opinion on Therapeutic Patents. 2005. [PMID: 39967341]