TGF Family
Transforming Growth Factor (TGF) beta superfamily consists of a group of proteins that can regulate numerous biological processes, such as cell growth, differentiation, apoptosis, and immune response. These proteins are involved in the regulation of many developmental processes including mesoderm induction, organogenesis, and tissue homeostasis. The TGF-β superfamily includes TGF-βs, activins, inhibins, bone morphogenetic proteins (BMPs), and others.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| Activin A | PCH90001 | GMP Recombinant Human Activin A | Human | 25.6 kDa |
| BMP-7 | PCH90002 | GMP Recombinant Human BMP-7 | Human | 36.5 kDa |
| TGF-β1 | PHH90058 | GMP Recombinant Human TGF-β1 | Human | 25 kDa |
| TGF-β2 | PCH90041 | GMP Recombinant Human TGF-β2 | Human | 25 kDa |
| TGF-β3 | PCH90042 | GMP Recombinant Human TGF-β3 | Human | 13 kDa |
Validation Data
GMP Recombinant Human Activin A (Catalog: PCH90001)
Activin A SDS-PAGE image
Activin A Bioactivity imageGMP Recombinant Human BMP-7 (Catalog: PCH90002)
BMP-7 SDS-PAGE image
Bioactivity image: The ED50 for this effect is 0.02-0.04 μg/ml.GMP Recombinant Human TGF-β1 (Catalog: PHH90058) GMP Recombinant Human TGF-β3 (Catalog: PCH90042)
TGF-β1 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤0.2ng/mL.GMP Recombinant Human TGF-β2 (Catalog: PCH90041)
TGF-β2 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤0.3ng/mL.References
1. Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications. Poniatowski ŁA, et al. Mediators Inflamm. 2015. [PMID: 25709154]
2. Structural biology of the TGFβ family. Goebel EJ, et al. Exp Biol Med (Maywood). 2019. [PMID: 31594405]
3. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y, et al. Cell. 2003. [PMID: 12809600]