IFN-β Rabbit Polyclonal Antibody

IFN-β Rabbit Polyclonal Antibody

Size1:50μl Price1:$118
Size2:100μl Price2:$220
Size3:500μl Price3:$980
SKU: APRab12402 Category: Polyclonal Antibody Tags: , ,

Datasheet

Summary

Production Name

IFN-β Rabbit Polyclonal Antibody

Description

Rabbit Polyclonal Antibody

Host

Rabbit

Application

IHC,

Reactivity

Human,Rat,Mouse

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Purification

Affinity purification

 

Immunogen

Gene Name

IFNB1 IFB IFNB

Alternative Names

Interferon beta (IFN-beta;Fibroblast interferon)

Gene ID

3456

SwissProt ID

P01574

 

Application

Dilution Ratio

IHC-p 1:50-200, ELISA 1:10000-20000.

Molecular Weight

 

Background

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015],function:Has antiviral, antibacterial and anticancer activities.,online information:Clinical information on Avonex,online information:Clinical information on Betaseron,pharmaceutical:Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.,similarity:Belongs to the alpha/beta interferon family.,subunit:Monomer.,

 

Research Area

Cytokine-cytokine receptor interaction;Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;Jak_STAT;Natural killer cell mediated cytotoxicity;