HLA-DQA1 Rabbit Polyclonal Antibody

HLA-DQA1 Rabbit Polyclonal Antibody

Size1:50μl Price1:$128
Size2:100μl Price2:$230
Size3:500μl Price3:$980
SKU: APRab12085 Category: Polyclonal Antibody Tags: , ,

Datasheet

Summary

Production Name

HLA-DQA1 Rabbit Polyclonal Antibody

Description

Rabbit Polyclonal Antibody

Host

Rabbit

Application

IHC,

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Purification

Affinity purification

 

Immunogen

Gene Name

HLA-DQA1

Alternative Names

HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain;DC-alpha;HLA-DCA;MHC class II DQA1)

Gene ID

100509457

SwissProt ID

P01909

 

Application

Dilution Ratio

IHC-p 1:50-200, ELISA 1:10000-20000.

Molecular Weight

 

Background

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrosimilarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,

 

Research Area

Cell adhesion molecules (CAMs);Antigen processing and presentation;Intestinal immune network for IgA production;Type I diabetes mellitus;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;Viral myocarditis;