Recombinant Human HRSP12 (N-6His)-Target Proteins-EnkiLife-Recombinant Proteins,Antibodies,Kits,Cell Biology

Recombinant Human HRSP12 (N-6His)

Size1:10μg price1:$89
Size2:50μg price2:$248
Size3:500μg price3:$1680 SKU: PEH0782 Category: Target Proteins Tags: Human, E.coli

Datasheet

Name	Recombinant Human HRSP12 (N-6His)
Purity	Greater than 95% as determined by reducing SDS-PAGE
Endotoxin level	<1 EU/µg as determined by LAL test.
Construction	Recombinant Human Heat-Responsive Protein 12 is produced by our E.coli expression system and the target gene encoding Met1-Leu137 is expressed with a 6His tag at the N-terminus.
Accession #	P52758
Host	E.coli
Species	Human
Predicted Molecular Mass	16.7 KDa
Buffer	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 8.0.
Form	Liquid
Shipping	The product is shipped on dry ice/polar packs.Upon receipt, store it immediately at the temperature listed below.
Stability&Storage	Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Alternative Names

Ribonuclease UK114; 14.5 kDa Translational Inhibitor Protein; p14.5; Heat-Responsive Protein 12; UK114 Antigen Homolog; HRSP12; PSP

Background

Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.

Note

For Research Use Only , Not for Diagnostic Use.