Phospho-Phospholamban (Ser16) Rabbit Monoclonal Antibody

Phospho-Phospholamban (Ser16) Rabbit Monoclonal Antibody

Size1:50μl Price1:$188
Size2:100μl Price2:$338
Size3:500μl Price3:$1200 SKU: AMRe02436 Category: Rabbit Monoclonal Antibody Tags: , , ,

Datasheet

Summary

Production Name

Phospho-Phospholamban (Ser16) Rabbit Monoclonal Antibody

Description

Recombinant Rabbit Monoclonal antibody

Host

Rabbit

Application

WB

Reactivity

Human,Mouse

 

Performance

Conjugation

Unconjugated

Modification

Phosphorylated

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification

Affinity Purified

 

Immunogen

Gene Name

PLN

Alternative Names

PLN; PLB; Cardiac phospholamban; PLB

Gene ID

5350

SwissProt ID

P26678

 

Application

Dilution Ratio

WB: 1/500-1/1000

Molecular Weight

Calculated MW: 6 kDa; Observed MW: 12,24 kDa

 

Background

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

 

Research Area

Signal Transduction

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