Bcl6 Rabbit Polyclonal Antibody-Polyclonal Antibody-EnkiLife-Recombinant Proteins,Antibodies,Kits,Cell Biology

Bcl6 Rabbit Polyclonal Antibody

Summary

Production Name	Bcl6 Rabbit Polyclonal Antibody
Description	Primary antibody
Host	Rabbit
Application	WB,ELISA
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Polyclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification	Affinity Purified

Immunogen

Gene Name	BCL6
Alternative Names	BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51
Gene ID	604
SwissProt ID	P41182

Application

Dilution Ratio	WB: 1/500-1/1000 ELISA: 1/10000
Molecular Weight	Calculated MW: 79 kDa; Observed MW: 79 kDa

Background

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions.HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs).

Research Area

Epigenetics and Nuclear Signaling