Recombinant Human IL-18BP (C-Fc)

Recombinant Human IL-18BP (C-Fc)

Size1:10μg price1:$58
Size2:50μg price2:$108
Size3:500μg price3:$690 SKU: PHH0884 Category: Cytokines Tags: ,

Datasheet

Name

Recombinant Human IL-18BP (C-Fc)

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Human Interleukin-18-binding Protein is produced by our Mammalian expression system and the target gene encoding Thr31-Gly194 is expressed with a human IgG1 Fc tag at the C-terminus.

Accession #

O95998-2

Host

Human Cells

Species

Human

Predicted Molecular Mass

44.8 KDa

Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Form

Lyophilized

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Interleukin-18-binding protein; Tadekinig-alfa and IL18BP

 

Background

Interleukin-18-binding protein, also known as Tadekinig-alfa and IL18BP, contains 1 Ig-like C2-type domain. IL18BP is constitutively expressed and secreted in mononuclear cells. IL18BP functions as an IL18 inhibitor. IL18BP binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. It has been shown that IL18BP may be a promising molecular approach to inhibit neointimal hyperplasia and arteriosclerosis progression following coronary and peripheral angioplasty.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

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