Alternative Names
Krueppel-Like Factor 6; B-Cell-Derived Protein 1; Core Promoter Element-Binding Protein; GC-Rich Sites-Binding Factor GBF; Proto-Oncogene BCD1; Suppressor of Tumorigenicity 12 Protein; Transcription Factor Zf9; KLF6; BCD1; COPEB; CPBP; ST12
Background
Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will result in gastric cancer and prostate cancer.
Note
For Research Use Only , Not for Diagnostic Use.
