Recombinant Human JAM-A (C-6His)

Recombinant Human JAM-A (C-6His)

Size1:10μg price1:$136
Size2:50μg price2:$378
Size3:500μg price3:$1890 SKU: PHH0611 Category: Target Proteins Tags: ,

Datasheet

Name

Recombinant Human JAM-A (C-6His)

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Human Junctional Adhesion Molecule A is produced by our Mammalian expression system and the target gene encoding Ser28-Val238 is expressed with a 6His tag at the C-terminus.

Accession #

Q9Y624

Host

Human Cells

Species

Human

Predicted Molecular Mass

23.89 KDa

Buffer

Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 100mM Glycine, pH 7.5.

Form

Lyophilized

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Junctional Adhesion Molecule A; JAM-A; Junctional Adhesion Molecule 1; JAM-1; Platelet F11 Receptor; Platelet Adhesion Molecule 1; PAM-1; CD321; F11R; JAM1; JCAM

 

Background

Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

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