Overview of APOA2 molecular target information
Overview of APOA2 molecular targets
Apolipoprotein AII (Apo A2) is the second most abundant apolipoprotein in human plasma high-density lipoprotein (HDL) after Apo A1 and is the most hydrophilic of the exchangeable apolipoproteins. Apo A2 is synthesized by the liver and small intestine and exists in plasma as a monomer or dimer. The Apo A2 gene consists of 4 exons and 3 introns. The four exons encode the 5' untranslated region, the propeptide, a short N-terminal domain, and a C-terminal domain consisting of a variable number of lipid-binding amphipathic helices. Apo A2 can stabilize the HDL structure by binding lipids and affect HDL metabolism. The role of Apo A2 in lipid metabolism and atherosclerosis has shown important clinical significance. Apo A2 levels are associated with increased susceptibility to atherosclerosis, free fatty acid levels, body fat, and insulin resistance.
Human APOA2 Molecular Target Information
Molecular name: APOA2, apolipoprotein A2
Alias:
- Apo-AII
- ApoA-II
- apoAII
- apolipoprotein A-II
Gene sequence:NCBI_Gene: 336
Protein sequence:UniProtKB: P02652
Human APOA2 target molecular function (prediction)
Enables several functions, including cholesterol binding activity; protein dimerization activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid transport; plasma lipoprotein particle organization; and lipid metabolic regulation of lipid metabolism process. Located in blood microparticle and extracellular exosome. Part of chylomicron; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in familial hypercholesterolemia. Biomarker of coronary artery disease; familial combined hyperlipidemia; obesity; type 1 diabetes mellitus; and type 2 diabetes mellitus.
Mouse Apoa2 molecular target information
Molecular name: Apoa2, apolipoprotein A-II
Alias:
- Alp-2
- Apoa-2
- ApoA-II
- Hdl-1
- high density lipoprotein 1
Gene sequence:NCBI_Gene: 11807
Protein sequence:
Mouse Apoa2 target molecular function (prediction)
Enables high-density lipoprotein particle binding activity. Acts upstream of or within several processes, including cholesterol homeostasis; negative regulation of lipase activity; and regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in alimentary system; embryo; liver; liver lobe; and lung. Human ortholog(s) of this gene implicated in familial hypercholesterolemia. Orthologous to human APOA2 (apolipoprotein A2).
Rat Apoa2 molecular target information
Molecular name: Apoa2, apolipoprotein A2
Alias:
- Apo-AII
- ApoA-II
- APOAII
- apolipoprotein A-II
Gene sequence:NCBI_Gene: 25649
Protein sequence:UniProtKB: P04638
Rat Apoa2 target molecular function (prediction)
Enables cholesterol transfer activity. Involved in several processes, including animal organ regeneration; response to estrogen; and response to glucocorticoid. Predicted to be located in extracellular space. Predicted to be part of chylomicron; spherical high-density lipoprotein particle; and very-low-density lipoprotein particle. Biomarker of hyperthyroidism. Human ortholog(s) of this gene implicated in familial hypercholesterolemia. Orthologous to human APOA2 (apolipoprotein A2).