Blog

APOE Molecular Target Information Overview


  • Molecular name: APOE, apolipoprotein E
  • Gene family: Apolipoproteins
  • Former name: AD2
  • Alias: Alzheimer disease 2 (APOE*E4-associated, late onset)


    • APOE molecular target review


    Apolipoprotein E (Apo E) is a class of apolipoproteins found in chylomicrons and intermediate-density lipoproteins and is essential for the normal metabolism of triglyceride-rich lipoprotein components. In peripheral tissues, Apo E is mainly produced by the liver and macrophages, mediating isomer-dependent cholesterol metabolism. In the central nervous system, Apo E is mainly produced by astrocytes and can transport cholesterol to neurons through the Apo E receptor. Apo E transports lipoproteins, fat-soluble vitamins, and cholesterol into the lymphatic system and then into the blood. In the field of immunomodulation, an increasing number of studies have pointed out that Apo E interacts with many immune processes, including inhibition of T cell proliferation, regulation of macrophage function, promotion of lipid antigen presentation to natural killer T cells, and regulation of inflammation and oxidation. Apo E secreted by monocytes is downregulated by inflammatory cytokines and upregulated by TGF-β. This protein is involved in Alzheimer's disease and cardiovascular disease.


    Human APOE Molecular Target Information


    Molecular name: APOE, apolipoprotein E


    Alias:

    • AD2
    • Alzheimer disease 2 (APOE*E4-associated, late onset)
    • apo-E
    • ApoE4
    • apolipoprotein E3
    • LDLCQ5
    • LPG
    • MGC1571

    Gene sequence:NCBI_Gene: 348

    Protein sequence:UniProtKB: P02649


    Human APOE target molecular function (prediction)


    Acts upstream of or within negative regulation of dendritic spine development; positive regulation of dendritic spine development; and regulation of dendritic spine maintenance. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and extracellular space. Part of several cellular components, including chylomicron; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Biomarker of several diseases, including Lewy body dementia; diabetes mellitus (multiple); end stage renal disease; neurodegenerative disease (multiple); and obesity.


    Mouse Apoe molecular target information


    Molecular name: Apoe, apolipoprotein E


    Alias:

    • AI255918
    • expressed sequence AI255918


    Gene sequence:NCBI_Gene: 11816

    Protein sequence:


    Mouse Apoe target molecular function (prediction)


    Acts upstream of or within several processes, including cholesterol catabolic process; cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including negative regulation of macromolecule metabolic process; plasma lipoprotein particle remodeling; and regulation of defense response. efflux; and lipoprotein metabolic process. Located in extracellular space and glutamatergic synapse. Part of low-density lipoprotein particle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and family hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).


    Rat Apoe molecular target information


    Molecular name: Apoe, apolipoprotein E

    Alias:

    • apo-E
    • APOEA

    Gene sequence:NCBI_Gene: 25728

    Protein sequence:


    Rat Apoe target molecular function (prediction)


    Enables several functions, including amyloid-beta binding activity; hydroxyapatite binding activity; and phospholipid binding activity. Involved in several processes, including cellular response to alcohol; neurogenesis; and regulation of lipid metabolism process. Located in several cellular components, including late endosome; neuronal cell body; and nuclear envelope. lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Colocalizes with early endosome and microtubule. Used to study artery disease (multiple); familial hyperlipidemia; fatty liver disease (multiple); glomerulosclerosis; and middle cerebral artery infarction. Biomarker of several diseases, including glomerulonephritis (multiple); hyperhomocysteinemia; hypertension; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).