Parkinson's disease (PD) is a common, chronic progressive degenerative disease of the nervous system, which mainly affects motor function and mostly occurs in middle-aged and elderly people. PD is characterized by the gradual degeneration of neurons in specific regions of the brain, namely the significant loss of dopaminergic neurons in the substantia nigra of the midbrain and the formation of intracellular Lewy bodies.
Alzheimer's disease (AD) is a progressively developing neurodegenerative disease and the most common type of Alzheimer's disease (approximately 60%-80% of all dementia cases. Its core features are progressive decline in cognitive functions (such as memory, thinking, language), as well as changes in behavior and personality, which ultimately lead to the loss of the ability to live independently. Existing studies have shown that the occurrence of AD is the result of the interaction of multiple factors such as abnormal protein aggregation, neuroinflammation, genetic factors, etc.
