I23O1_HUMAN P14902
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UniProt:P14902
Recommended name：Indoleamine 2,3-dioxygenase 1
EC number：EC:1.13.11.52
Alternative names：(IDO-1) (Indoleamine-pyrrole 2,3-dioxygenase)
Cleaved into：
GeneID：3620
Gene names (primary )：IDO1
Gene names (synonym )：IDO INDO
Gene names (ORF )：
Length：403
Mass：45326
Sequence：MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Tissue specificity：Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:26155395, PubMed:25691885). {ECO:0000269|PubMed:18418598, ECO:0000269|PubMed:25691885, ECO:0000269|PubMed:26155395}.
Induction：By IFNG/IFN-gamma in most cells (PubMed:2109605, PubMed:1907934). Exogenous inflammatory stimuli induce the expression of IDO1 in antigen-presenting cells such as dendritic cells, macrophages and B-cells (PubMed:25157255). {ECO:0000269|PubMed:2109605, ECO:0000303|PubMed:1907934, ECO:0000303|PubMed:25157255}.
Developmental stage：
Protein families：Indoleamine 2,3-dioxygenase family