MGST2_HUMAN Q99735
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UniProt:Q99735
Recommended name：Microsomal glutathione S-transferase 2
EC number：EC:2.5.1.18
Alternative names：(Microsomal GST-2) (Glutathione peroxidase MGST2) (Leukotriene C4 synthase MGST2) (Microsomal glutathione S-transferase II) (Microsomal GST-II)
Cleaved into：
GeneID：4258
Gene names (primary )：MGST2
Gene names (synonym )：GST2
Gene names (ORF )：
Length：147
Mass：16621
Sequence：MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF
Tissue specificity：Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034). Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876). {ECO:0000269|PubMed:11322876, ECO:0000269|PubMed:8703034}.
Induction：Upon ER stress with brefeldin A or with tunicamycin, MGST2 is down-regulated, in several non-haematopoietic cell types, during the early, protective phase of the unfolded protein response (UPR), and up-regulated at the late, death-promoting phase of the unfolded protein response (UPR). {ECO:0000269|PubMed:26656251}.
Developmental stage：
Protein families：MAPEG family