CH3L1_HUMAN P36222
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UniProt:P36222
Recommended name：Chitinase-3-like protein 1
EC number：
Alternative names：(39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)
Cleaved into：
GeneID：1116
Gene names (primary )：CHI3L1
Gene names (synonym )：
Gene names (ORF )：
Length：383
Mass：42625
Sequence：MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT
Tissue specificity：Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:9492324}.
Induction：Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:20558631}.
Developmental stage：
Protein families：Glycosyl hydrolase 18 family