K2C6A_MOUSE P50446
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UniProt:P50446
Recommended name：Keratin, type II cytoskeletal 6A
EC number：
Alternative names：(Cytokeratin-6A) (CK-6A) (Keratin-6-alpha) (mK6-alpha) (Keratin-6A) (K6A)
Cleaved into：
GeneID：16687
Gene names (primary )：Krt6a
Gene names (synonym )：Ker2 Krt2-6 Krt2-6a Krt6
Gene names (ORF )：
Length：553
Mass：59335
Sequence：MSTKTTIKSQTSHRGYSASSARVPGLNRSGFSSVSVCRSRGSGGSSAMCGGAGFGSRSLYGVGSSKRISIGGGSCGIGGGYGSRFGGSFGIGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTINQSLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQNLEPMFEQYISNLRRQLDSIIGERGRLDSELRNMQDTVEDYKSKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADSLTDDINFLRALYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDARGKLEGLEDALQKAKQDMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSAGGASSSLGLGGGSSYSYSSSHGLGGGFSAGSGRAIGGGLSSSGGLSSSTIKYTTTSSSKKSYRQ
Tissue specificity：Predominates in the adult trunk skin, tongue, trachea/esophagus and eye. In adult skin, localization is restricted to hair follicles, where it is localized predominantly in the outer root sheath. {ECO:0000269|PubMed:11069616, ECO:0000269|PubMed:9790766}.
Induction：With the exception of specific body sites, expression is induced under conditions of epithelial hyperproliferation such as wound healing, certain skin diseases, cancer, and by treatment of the skin with the phorbol ester PMA. Upon wounding, induced in the outer root sheath and the interfollicular epidermis including the basal cell layer (PubMed:10866680). {ECO:0000269|PubMed:10866680, ECO:0000269|PubMed:8636216, ECO:0000269|PubMed:9790766}.
Developmental stage：
Protein families：Intermediate filament family