GPNMB_MOUSE Q99P91
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UniProt:Q99P91
Recommended name：Transmembrane glycoprotein NMB
EC number：
Alternative names：(DC-HIL) (Dendritic cell-associated transmembrane protein) (Osteoactivin)
Cleaved into：
GeneID：93695
Gene names (primary )：Gpnmb
Gene names (synonym )：Dchil Hgfin Nmb
Gene names (ORF )：
Length：574
Mass：63676
Sequence：MESLCGVLGFLLLAAGLPLQAAKRFRDVLGHEQYPDHMREHNQLRGWSSDENEWDEHLYPVWRRGDGRWKDSWEGGRVQAVLTSDSPALVGSNITFVVNLVFPRCQKEDANGNIVYEKNCRNDLGLTSDLHVYNWTAGADDGDWEDGTSRSQHLRFPDRRPFPRPHGWKKWSFVYVFHTLGQYFQKLGRCSARVSINTVNLTAGPQVMEVTVFRRYGRAYIPISKVKDVYVITDQIPVFVTMSQKNDRNLSDEIFLRDLPIVFDVLIHDPSHFLNDSAISYKWNFGDNTGLFVSNNHTLNHTYVLNGTFNLNLTVQTAVPGPCPPPSPSTPPPPSTPPSPPPSPLPTLSTPSPSLMPTGYKSMELSDISNENCRINRYGYFRATITIVEGILEVSIMQIADVPMPTPQPANSLMDFTVTCKGATPMEACTIISDPTCQIAQNRVCSPVAVDGLCLLSVRRAFNGSGTYCVNFTLGDDASLALTSTLISIPGKDPDSPLRAVNGVLISIGCLAVLVTMVTILLYKKHKAYKPIGNCPRNTVKGKGLSVLLSHAKAPFFRGDQEKDPLLQDKPRTL
Tissue specificity：May be up-regulated in bone metastatic breast cancer cells. {ECO:0000269|PubMed:17951401}.
Induction：
Developmental stage：At 9.5-10.5 dpc, highly expressed in the developing eye, restricted to the outer layer of the retina. At midgestation development, expression gets restricted to the forming retinal pigment layer. At 18.5 dpc, expression remains high in the retinal pigment epithelium and is also observed at the forming iris. {ECO:0000269|PubMed:12638126}.
Protein families：PMEL/NMB family