EZH2_MOUSE Q61188
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:Q61188
Recommended name：Histone-lysine N-methyltransferase EZH2
EC number：EC 2.1.1.356
Alternative names：(ENX-1) (Enhancer of zeste homolog 2)
Cleaved into：
GeneID：14056
Gene names (primary )：Ezh2
Gene names (synonym )：Enx1h
Gene names (ORF )：
Length：746
Mass：85292
Sequence：MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
Tissue specificity：Present in actively dividing cells (PubMed:19026781). Widely expressed in early embryos (PubMed:19026781). In later embryogenesis, expression restricted to central and peripheral nervous system, liver and thymus (PubMed:19026781). In adult, highest expression in spleen, testis and placenta (PubMed:19026781, PubMed:31451685). Lower levels in intestine, muscle and ovary and very low levels in brain and liver (PubMed:19026781, PubMed:31451685). No expression in heart, thyroid gland, lung and kidney (PubMed:19026781). {ECO:0000269|PubMed:19026781, ECO:0000269|PubMed:31451685}.
Induction：Repressed by the microRNA (miRNA) miR-26a. {ECO:0000269|PubMed:18281287}.
Developmental stage：Expressed in both adult and embryo with highest levels in early embryogenesis. Expressed in the fertilized oocyte. Expression decreases during differentiation of ES cells and during senescence of MEFs. Expression increases in prostate during prostate tumor development. {ECO:0000269|PubMed:12689588, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:17344414}.
Protein families：Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily