OSTM1_MOUSE Q8BGT0
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UniProt:Q8BGT0
Recommended name:Osteopetrosis-associated transmembrane protein 1
EC number:
Alternative names:(Chloride channel 7 beta subunit) (Grey-lethal protein)
Cleaved into:
GeneID:14628
Gene names (primary ):Ostm1
Gene names (synonym ):Gl
Gene names (ORF ):
Length:338
Mass:38000
Sequence:MARDAELARSSGWPWRWLPALLLLQLLRWRCALCALPFTSSRHPGFADLLSEQQLLEVQDLTLSLLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAIKMDNISRNIGNTSEGPRCGGSLLTADRMQIVLMVSEFFNSTWQEANCANCLTNNGEDLSNNTEDFLSLFNKTLACFEHNLQGHTYSLLPPKNYSEVCRNCKEAYKNLSLLYSQMQKLNGLENKAEPETHLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLILPKRLKSSTSFANIQENAT
Tissue specificity:Expressed primarily in osteoclasts and melanocytes as well as brain, kidney and spleen. Found at lower levels in the thymus, testis, heart and liver. {ECO:0000269|PubMed:12627228}.
Induction:
Developmental stage:Expression was detected in fetal liver neuronal and bone tissues (12.5 dpc and 15.5 dpc). High expression was detected in thymus and gut at 18.5 dpc and continued postnatally. Expression in bone (mandible and vertebrae) and brain tissues (cerebellum, hippocampus and cortex) remained high after birth. In addition high expression was detected in kidney, spleen and skin at P5 and P10. {ECO:0000269|PubMed:12627228}.
Protein families:OSTM1 family