TISD_MOUSE P23949
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:P23949
Recommended name：mRNA decay activator protein ZFP36L2
EC number：
Alternative names：(Butyrate response factor 2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)
Cleaved into：
GeneID：12193
Gene names (primary )：Zfp36l2
Gene names (synonym )：Tis11d
Gene names (ORF )：
Length：484
Mass：50070
Sequence：MSTTLLSPFYDIDFLCKTEKSLANLNLNNMLDKKAVGTPVAAAPSSSFTPGFLRRHSASNLHALAHPVPSPGSCSPKFPGAPNGGGSSCGPAGGGGLASYGQLKEPSGGSGTALVTKESKFRDRSFSENGERSQHLLHLQQQQKGGSGSQINSTRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNADERRPAPSGGGGASGDLRAFGARDALHLGFAREPRPKLHHSLSFSGFPSGHHQPPGGLESPLLLDSPTSRTPPPPSSSASSCSSSASSCSSASAASTPSGAPTCCATAAAAALLYGPGGAEDLLSPGAPCASCSSSGANNAFAFGPELSSLITPLAIQTHNFAAAAAAAYYRNQQQGLTGPAPPPAQPPAAPAPPSPPFGFQLPRRLSESPVFDAPPSPPDSLSDRDSYLSGSLSSGSLSGSESPSLDPGRRLPIFSRLSISDD
Tissue specificity：Expressed in preadipocytes and adipocytes (at protein level) (PubMed:22701344). Expressed at highest level in lymphoid tissues such as thymus, spleen, lung, uterus, ovary, small and large intestine, mammary gland, fat and bone marrow (PubMed:19633199, PubMed:22367205). Expressed at intermediate level in kidney, heart, adrenal, eye and fetal liver (PubMed:19633199). Weakly expressed in brain, skeletal muscle and liver (PubMed:19633199, PubMed:22367205). Expressed through B lymphocyte development (PubMed:27102483). Expressed in superior cervical ganglion (SCG) and dorsal root ganglion (DRG) (PubMed:25505318). Expressed in embryonic stem cells (ESCs) (PubMed:24733888). {ECO:0000269|PubMed:19633199, ECO:0000269|PubMed:22367205, ECO:0000269|PubMed:22701344, ECO:0000269|PubMed:24733888, ECO:0000269|PubMed:25505318, ECO:0000269|PubMed:27102483}.
Induction：Up-regulated in response to fibroblast growth factor FGF4 in embryonic stem cells (ESCs) in a p38 MAPK-dependent manner (at protein level) (PubMed:24733888). Up-regulated by glucocorticoid agonists, such as dexamethasone (DEX), in burst-forming unit-erythroid (BFU-E) progenitors in a receptor NR3C1-dependent manner (PubMed:23748442). Down-regulated during erythroid cell differentiation (PubMed:23748442). Down-regulated during the conversion from quiescence to activated satellite cells upon muscle injury (PubMed:23046558, PubMed:25815583). {ECO:0000269|PubMed:23046558, ECO:0000269|PubMed:23748442, ECO:0000269|PubMed:24733888, ECO:0000269|PubMed:25815583}.
Developmental stage：In embryos, expression is detected at 7 dpc, increases at 9.5 dpc, and then remains constant through 18.5 dpc (PubMed:19633199). Expression in the yolk sac is relatively constant between 10.5 dpc and 18.5 dpc (PubMed:19633199). Placenta expression is also constant throughout development with a slight decrease observed at 18.5 dpc (PubMed:19633199). Expressed in burst-forming unit-erythroid (BFU-E) progenitor cells and down-regulated as erythroid cells differentiate (PubMed:23748442). {ECO:0000269|PubMed:19633199, ECO:0000269|PubMed:23748442}.
Protein families：