GGN_MOUSE Q80WJ1
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UniProt:Q80WJ1
Recommended name：Gametogenetin
EC number：
Alternative names：
Cleaved into：
GeneID：243897
Gene names (primary )：Ggn
Gene names (synonym )：
Gene names (ORF )：
Length：673
Mass：68892
Sequence：MGNVQSEPSAGGGSRKEQASDRASDSRRTPLVEPEVTPSSPAMRLARGLGVWFPGSSGPPGLLIPPEPQASSSPLPLTLELPSPVTPPPEEAAAVSTPPPPPVGTLLPAPSKWRKPTGTSVPRIRGLLEASHRGQGDPPSLRPLPPLPRQLTEKDPVLRAPAPPPTPLEPRKQLPPAPSTCDPQPLSRRITLASSATSPTESQVRHSSEGQAAGGAHGGVPPQAGEGEMARSATSESGLSLLCKVTFKSGPHLSPTSASGPLAAKASPGAGGGGLFASSGAISYAEVLKQGPQPPGATRPLGEVPPGATRPLGEVPRAAQETEGGDGDGEGCSGPPSVPAPLARALPPPPYTTFPGSKPKFDWVSPPDGTERHFRFNGAVGGIGAPRRRTTTLSGPWGSPPPRSGQTHPSSGPRRPTPALLAPPMFIFPAPNNGEPVRPVPPSPQQIPPLPPPPPTPPATPPPAPPPTPQPPALPRTPILVARPPTPGPGHLESALAPTPPSTLSPTAAADQVPAATPATVTSQVPATATAELSPPMPQPKTRTRRNKGPRAARGVIREEGTSGDGPREPNTAPVTDSSSGGGGGGSNGTSTAGASNKGTARHWPPFEVLNSCPCKCYCRHQRRHRRLPRNVSAWLSTPTNHLSEPPWVATVKLAGSLVAGLEHYDLQATHST
Tissue specificity：Testis-specific. Specifically expressed in the germ cells and not in the somatic, Sertoli, or Leydig cells. In adult testis, expression starts in stage VIII pachytene spermatocytes, increases in stage IX and X pachytene spermatocytes, and culminates in stage XI diplotene spermatocytes and the meiotic cells in stage XII. Expression decreases slightly in step 1-3 spermatids, further decreases in step 4-11 spermatids, and is no longer detectable in step 12 spermatids and beyond. Isoform 2 is mainly expressed in testis. {ECO:0000269|PubMed:12574169}.
Induction：
Developmental stage：Isoform 2 is detected at high level in adult testis and at lower level in 19-day testis. Not detected in 14-day testis (at protein level). In the developing postnatal gonad, it is not expressed in 6-day-old testes in which the germ cells are almost exclusively spermatogonia or 14-day testis in which the most advanced germ cells are early pachytene spermatocytes. However, it is expressed in 21-day testis tubules containing late pachytene spermatocytes or spermatids. In the postnatal male testis, it is strictly confined to late pachytene spermatocytes through spermatids, a time during which meiosis takes place. {ECO:0000269|PubMed:12574169, ECO:0000269|PubMed:15892049}.
Protein families：