Summary
Performance
Immunogen
Application
Background
This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],function:The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer with IL20RB and heterodimer with IL10RB.,tissue specificity:Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.,
Research Area
Cytokine-cytokine receptor interaction;Jak_STAT;
