Recombinant Human ANGPTL8 (N-Fc)

Recombinant Human ANGPTL8 (N-Fc)

Size1:10μg price1:$168
Size2:50μg price2:$465
Size3:500μg price3:$2350 SKU: PHH0063 Category: Target Proteins Tags: ,

Datasheet

Name

Recombinant Human ANGPTL8 (N-Fc)

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Human Angiopoietin-like Protein 8 is produced by our Mammalian expression system and the target gene encoding Ala22-Ala198 is expressed with a human IgG1 Fc tag at the N-terminus.

Accession #

Q6UXH0

Host

Human Cells

Species

Human

Predicted Molecular Mass

46 KDa

Buffer

Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Trehalose, 0.05% Tween80, pH8.0.

Form

Lyophilized

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Betatrophin;Angiopoietin-like protein 8;Lipasin;Angptl8

 

Background

The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

Related products