Annexin VI Rabbit Polyclonal Antibody

Annexin VI Rabbit Polyclonal Antibody

Size1:50μl Price1:$118
Size2:100μl Price2:$220
Size3:500μl Price3:$980
SKU: APRab06927 Category: Polyclonal Antibody Tags: , , , , ,

Datasheet

Summary

Production Name

Annexin VI Rabbit Polyclonal Antibody

Description

Rabbit Polyclonal Antibody

Host

Rabbit

Application

IF,IHC,WB,ELISA

Reactivity

Human,Rat,Mouse

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Purification

Affinity purification

 

Immunogen

Gene Name

ANXA6

Alternative Names

ANXA6; ANX6; Annexin A6; 67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70

Gene ID

309

SwissProt ID

P08133

 

Application

Dilution Ratio

WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.

Molecular Weight

75kD

 

Background

Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010],caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,function:May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.,induction:By EBV.,miscellaneous:Seems to bind one calcium ion with high affinity.,PTM:Phosphorylated in response to growth factor stimulation.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,similarity:Contains 8 annexin repeats.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,

 

Research Area