Recombinant Mouse GITR (C-Fc-6His)

Recombinant Mouse GITR (C-Fc-6His)

Size1:10μg price1:$89
Size2:50μg price2:$248
Size3:500μg price3:$1240 SKU: PHM0339 Category: Target Proteins Tags: ,

Datasheet

Name

Recombinant Mouse GITR (C-Fc-6His)

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Ser22-His153 is expressed with a human IgG1 Fc, 6His tag at the C-terminus.

Accession #

O35714

Host

Human Cells

Species

Mouse

Predicted Molecular Mass

42.3 KDa

Buffer

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 5% Sucrose, 5% Dextran-70，0.05% Tween 80, pH8.0.

Form

Lyophilized

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Tumor necrosis factor receptor superfamily member 18;Glucocorticoid-induced TNFR-related protein;Tnfrsf18; AITR;CD357;GITR-D;TNFRSF18

 

Background

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

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