Dexras2 Rabbit Polyclonal Antibody

Dexras2 Rabbit Polyclonal Antibody

Size1:50μl Price1:$118
Size2:100μl Price2:$220
Size3:500μl Price3:$980
SKU: APRab09932 Category: Polyclonal Antibody Tags: , ,

Datasheet

Summary

Production Name

Dexras2 Rabbit Polyclonal Antibody

Description

Rabbit Polyclonal Antibody

Host

Rabbit

Application

WB

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Purification

Affinity purification

 

Immunogen

Gene Name

RASD2

Alternative Names

RASD2; TEM2; GTP-binding protein Rhes; Ras homolog enriched in striatum; Tumor endothelial marker 2

Gene ID

23551

SwissProt ID

Q96D21

 

Application

Dilution Ratio

WB 1:500-1:2000. ELISA: 1:40000.

Molecular Weight

35kD

 

Background

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016],function:Binds to GTP and possesses intrinsic GTPase activity. May play a role in mediating signal transduction (By similarity). May be involved in mediating the insulin secretory response to efaroxan.,similarity:Belongs to the small GTPase superfamily. RasD family.,subunit:Monomer .,tissue specificity:Pancreatic endocrine cells (islets of Langerhans).,

 

Research Area