GMP Recombinant Human IL-6

GMP Recombinant Human IL-6

Size1:10μg price1:$174
Size2:50μg price2:$580
Size3:1mg price3:Please Inquire
SKU: PCH90030 Category: GMP Cytokines Tags: , ,

Datasheet

Product Name

GMP Recombinant Human IL-6

Full Name

IL-6

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

≤10 EU/mg

Construction

Recombinant Human IL-6 is produced by our Mammalian cell expression system and the target gene encoding Val30-Met212 is expressed.

Accession #

P05231

tag

Tag free

Host

Mammalian cell

Species

Human

PredictedMolecularMass

20.8 kDa

Form

Lyophilized

Buffer

PBS,5% mannitol and 0.01% Tween 80, pH7.4

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2

 

Bioactivity

The ED50 for this effect is 0.2-1 ng/mL.

 

Background

Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.

 

Note

For Research Use Only , Not for Diagnostic Use.