Alternative Names
Multiple Inositol Polyphosphate Phosphatase 1; 2;3-Bisphosphoglycerate 3-Phosphatase; 2;3-BPG Phosphatase; Inositol (1;3;4;5)-Tetrakisphosphate 3-Phosphatase; Ins(1;3;4;5)P(4) 3-Phosphatase; MINPP1; MIPP
Background
Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). MINPP1 may play a role in bone development (endochondral ossification).
Note
For Research Use Only , Not for Diagnostic Use.
