Alternative Names
Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNAmethyltransferase;O-6-methylguanine-DNA-alkyltransferase; MGMT
Background
MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.
Note
For Research Use Only , Not for Diagnostic Use.
