Summary
Performance
Immunogen
Application
Background
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.MiscellaneousS-II binds to RNA-polymerase II in the absence of transcription.
Research Area
Epigenetics and Nuclear Signaling
