PI3 Kinase p85 alpha Rabbit Monoclonal Antibody-Rabbit Monoclonal Antibody-EnkiLife-Recombinant Proteins,Antibodies,Kits,Cell Biology

PI3 Kinase p85 alpha Rabbit Monoclonal Antibody

Summary

Production Name	PI3 Kinase p85 alpha Rabbit Monoclonal Antibody
Description	Recombinant Rabbit Monoclonal antibody
Host	Rabbit
Application	WB,ICC/IF
Reactivity	Human,Rat,Hamster

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Monoclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification	Affinity Purified

Immunogen

Gene Name	PIK3R1
Alternative Names	PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha
Gene ID	5295
SwissProt ID	P27986

Application

Dilution Ratio	WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Molecular Weight	Calculated MW: 84 kDa; Observed MW: 84 kDa

Background

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.

Research Area

Signal Transduction