NTH1 Rabbit Monoclonal Antibody

NTH1 Rabbit Monoclonal Antibody

Size1:50μl Price1:$158
Size2:100μl Price2:$288
Size3:500μl Price3:$1200
SKU: AMRe02358 Category: Rabbit Monoclonal Antibody Tags: , , , ,

Datasheet

Summary

Production Name

NTH1 Rabbit Monoclonal Antibody

Description

Recombinant Rabbit Monoclonal antibody

Host

Rabbit

Application

WB,ICC/IF

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification

Affinity Purified

 

Immunogen

Gene Name

NTHL1

Alternative Names

FAP3; NTH1; OCTS3; hNTH1

Gene ID

4913

SwissProt ID

P78549

 

Application

Dilution Ratio

WB: 1/500-1/1000 IF: 1/50-1/200

Molecular Weight

Calculated MW: 34 kDa; Observed MW: 34 kDa

 

Background

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

 

Research Area

Epigenetics and Nuclear Signaling