LEF1 Rabbit Polyclonal Antibody-Polyclonal Antibody-EnkiLife-Recombinant Proteins,Antibodies,Kits,Cell Biology

LEF1 Rabbit Polyclonal Antibody

Summary

Production Name	LEF1 Rabbit Polyclonal Antibody
Description	Primary antibody
Host	Rabbit
Application	WB,IHC
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG
Clonality	Polyclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	Affinity Chromatography

Immunogen

Gene Name	LEF1
Alternative Names	LEF1; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha
Gene ID	51176
SwissProt ID	Q9UJU2

Application

Dilution Ratio	WB: 1/500-1/1000 IHC: 1/50-1/100
Molecular Weight	Calculated MW: 44 kDa; Observed MW: 44 kDa

Background

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity).

Research Area

Epigenetics and Nuclear Signaling