PTCH1 Rabbit Polyclonal Antibody

PTCH1 Rabbit Polyclonal Antibody

Size1:50μl Price1:$150
Size2:100μl Price2:$280
Size3:500μl Price3:$1200
SKU: APRab00420 Category: Polyclonal Antibody Tags: , , , , ,

Datasheet

Summary

Production Name

PTCH1 Rabbit Polyclonal Antibody

Description

Primary antibody

Host

Rabbit

Application

WB,IHC,ELISA

Reactivity

Human,Mouse

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Chromatography

 

Immunogen

Gene Name

PTCH1

Alternative Names

PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1

Gene ID

5727

SwissProt ID

Q13635

 

Application

Dilution Ratio

IHC: 1/50-1/100 ELISA: 1/10000

Molecular Weight

Calculated MW: 161 kDa; Observed MW: 161 kDa

 

Background

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

 

Research Area

Cell Biology