Alternative Names
Aldo-Keto Reductase Family 1 Member C4; 3-Alpha-HSD1; 3-Alpha-Hydroxysteroid Dehydrogenase Type I; Chlordecone Reductase; CDR; Dihydrodiol Dehydrogenase 4; DD-4; DD4; HAKRA; AKR1C4; CHDR
Background
Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.
Note
For Research Use Only , Not for Diagnostic Use.
