IL-17 Receptor C Rabbit Polyclonal Antibody

IL-17 Receptor C Rabbit Polyclonal Antibody

Size1:50μl Price1:$150
Size2:100μl Price2:$280
Size3:500μl Price3:$1200
SKU: APRab00404 Category: Polyclonal Antibody Tags: , , , ,

Datasheet

Summary

Production Name

IL-17 Receptor C Rabbit Polyclonal Antibody

Description

Primary antibody

Host

Rabbit

Application

WB,ELISA

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Chromatography

 

Immunogen

Gene Name

IL17RC

Alternative Names

IL17RC; Interleukin-17 receptor C; IL-17 receptor C; IL-17RC; Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14

Gene ID

84818

SwissProt ID

Q8NAC3

 

Application

Dilution Ratio

WB: 1/500-1/1000 ELISA: 1/10000

Molecular Weight

Calculated MW: 86 kDa; Observed MW: 70 kDa

 

Background

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

 

Research Area

Immunology