CRK (3H7) Mouse Monoclonal Antibody

CRK (3H7) Mouse Monoclonal Antibody

Size1:50μl Price1:$150
Size2:100μl Price2:$280
Size3:500μl Price3:$1200 SKU: AMM03483 Category: Mouse Monoclonal Antibody Tags: , , ,

Datasheet

Summary

Production Name

CRK (3H7) Mouse Monoclonal Antibody

Description

Primary antibody

Host

Mouse

Application

WB

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG2b

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purified

 

Immunogen

Gene Name

CRK

Alternative Names

Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk

Gene ID

1398

SwissProt ID

P46108

 

Application

Dilution Ratio

WB: 1/500-1/1000

Molecular Weight

Calculated MW: 34 kDa; Observed MW: 34 kDa

 

Background

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

 

Research Area

Neuroscience

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