Alternative Names
Cytokine receptor-like factor 2; Cytokine receptor-like 2; TSLP receptor; CRL2; ILXR; TSLPR; Interleukin-7 receptor subunit alpha; IL-7R subunit alpha; IL-7RA; CD127
Background
The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. IL-7 and IL-7Ralpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. TSLP, forming a triple complex of TSLP/TSLPR/IL-7Rα, activates JAK1 and JAK2, thereby resulting in phosphorylation of STAT5A and STAT5B, as well as STAT1, STAT3, and other STAT proteins to a lesser extent, and MAPKs and NF-κB depending on the cell type.
Note
For Research Use Only , Not for Diagnostic Use.
