Recombinant Rhesus Macaque ICAM-1 (C-Fc)

Recombinant Rhesus Macaque ICAM-1 (C-Fc)

Size1:10μg price1:$89
Size2:50μg price2:$248
Size3:500μg price3:$1780 SKU: PHV2384 Category: Target Proteins Tags: ,

Datasheet

Name

Recombinant Rhesus Macaque ICAM-1 (C-Fc)

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Intercellular adhesion molecule 1 is produced by our Mammalian expression system and the target gene encoding Gln28-Glu480 is expressed with a human IgG1 Fc tag at the C-terminus.

Accession #

Q5NKV6

Host

Human Cells

Species

Rhesus Macaque

Predicted Molecular Mass

76.3 KDa

Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Form

Lyophilized

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Intercellular adhesion molecule 1; ICAM1; ICAM-1; CD54

 

Background

Intercellular adhesion molecule 1 (ICAM1) is known as CD54. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

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