Recombinant Human CD161 (N-Fc)

Recombinant Human CD161 (N-Fc)

Size1:10μg price1:$89
Size2:50μg price2:$248
Size3:500μg price3:$1980 SKU: PHH2377 Category: Target Proteins Tags: ,

Datasheet

Name

Recombinant Human CD161 (N-Fc)

Purity

Greater than 95% as determined by reducing SDS-PAGE

Endotoxin level

<1 EU/µg as determined by LAL test.

Construction

Recombinant Human Killer cell lectin-like receptor subfamily B member 1 is produced by our Mammalian expression system and the target gene encoding Lys68-Ser225 is expressedwith a human IgG1 Fc tag at the N-terminus.

Accession #

Q12918

Host

Human Cells

Species

Human

Predicted Molecular Mass

45 KDa

Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Form

Lyophilized

Shipping

The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.

Stability&Storage

Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Reconstitution

Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

 

 

 

Alternative Names

Killer cell lectin-like receptor subfamily B member 1;KLRB1;CLEC5B; NKRP1A;CD161;Natural killer cell surface protein P1A;NKR-P1A;HNKR-P1a;C-type lectin domain family 5 member B;KLRB1

 

Background

Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

 

Note

For Research Use Only , Not for Diagnostic Use.

 

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