Summary
Performance
Immunogen
Application
Background
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,enzyme regulation:Partially inhibited by phosphatidylserine.,function:May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis.,PTM:Isoform 1 H domain is phosphorylated.,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:The two isoforms are able to form homo- and hetero-oligomer structures (at least tetramers).,tissue specificity:Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.,
Research Area
Glycerolipid metabolism;Glycerophospholipid metabolism;Phosphatidylinositol signaling system;
