Summary
Performance
Immunogen
Application
Background
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016],catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,induction:By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).,online information:CYP1A1 alleles,online information:CYP1A1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Lung, lymphocytes and placenta.,
Research Area
Steroid hormone biosynthesis;Tryptophan metabolism;Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;
