Summary
Performance
Immunogen
Application
Background
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010],catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:High levels in adult and fetal brain, kidney and lung; low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver.,
Research Area
MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Chemokine;Oocyte meiosis;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Vascular smooth muscle contraction;WNT;WNT-T CELLHedgehog;Gap junction;Long-term potentiation;Olfactory transduction;Taste transduction;Insulin_Receptor;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Prion diseases;Vibrio cholerae infection;Dilated cardiomyopathy;
