Phospho-ErbB3 (Y1222) (11E17) Rabbit Monoclonal Antibody

Phospho-ErbB3 (Y1222) (11E17) Rabbit Monoclonal Antibody

Size1:50μl Price1:$138
Size2:100μl Price2:$240
Size3:500μl Price3:$980 SKU: AMRe05900 Category: Rabbit Monoclonal Antibody Tags: , , ,

Datasheet

Summary

Production Name

Phospho-ErbB3 (Y1222) (11E17) Rabbit Monoclonal Antibody

Description

Rabbit Monoclonal Antibody

Host

Rabbit

Application

WB,ELISA

Reactivity

Human

 

Performance

Conjugation

Unconjugated

Modification

Phospho Antibody

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Purification

Affinity purification

 

Immunogen

Gene Name

ERBB3

Alternative Names

ERBB3; HER3; LCCS2; p180 ErbB3; p45 sErbB3; p85 sErbB3;

Gene ID

2065

SwissProt ID

P21860

 

Application

Dilution Ratio

WB 1:500-1:2000

Molecular Weight

148kDa

 

Background

Binds and is activated by neuregulins and NTAK. Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).

 

Research Area

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