GNPAT Rabbit Polyclonal Antibody

GNPAT Rabbit Polyclonal Antibody

Size1:50μl Price1:$118
Size2:100μl Price2:$220
Size3:500μl Price3:$980
SKU: APRab11564 Category: Polyclonal Antibody Tags: , , , ,

Datasheet

Summary

Production Name

GNPAT Rabbit Polyclonal Antibody

Description

Rabbit Polyclonal Antibody

Host

Rabbit

Application

WB,IHC,ELISA

Reactivity

Human,Rat,Mouse

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Polyclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Purification

Affinity purification

 

Immunogen

Gene Name

GNPAT

Alternative Names

GNPAT; DAPAT; DHAPAT; Dihydroxyacetone phosphate acyltransferase; DAP-AT; DHAP-AT; Acyl-CoA:dihydroxyacetonephosphateacyltransferase; Glycerone-phosphate O-acyltransferase

Gene ID

8443

SwissProt ID

O15228

 

Application

Dilution Ratio

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000..

Molecular Weight

77kD

 

Background

This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],catalytic activity:Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.,disease:Defects in GNPAT are the cause of rhizomelic chondrodysplasia punctata type 2 (RCDP2) [MIM:222765]. RDCP2 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,pathway:Membrane lipid metabolism; glycerophospholipid metabolism.,similarity:Belongs to the GPAT/DAPAT family.,subcellular location:Exclusively localized to the lumenal side of the peroxisomal membrane.,subunit:May be part of an heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT.,

 

Research Area

Glycerophospholipid metabolism;