NBR1(7C3)Mouse Monoclonal Antibody

NBR1(7C3)Mouse Monoclonal Antibody

Size1:50μL Price1:$118
Size2:100μL Price2:$220
Size3:200μL Price3:$380
Application:IF-P,IF-F,ICC/IF,IHC-P
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:NBR1 SKU: AMM14433 Category: Mouse Monoclonal Antibody Tags: , , , , , , ,

Summary

Production Name

NBR1(7C3)Mouse Monoclonal Antibody

Description

Mouse Monoclonal Antibody

Host

Mouse

Application

IF-P,IF-F,ICC/IF,IHC-P

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Purification

Affinity purification

 

Immunogen

Gene Name

NBR1

Alternative Names

Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)

Gene ID

4077

SwissProt ID

Q14596

 

Application

Dilution Ratio

IF-P/IF-F/ICC/IF 1:50-200, IHC-P 1:50-300

Molecular Weight

120kDa

 

Background

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],caution:Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125.,domain:The OPR domain mediates interaction with SQSTM1.,similarity:Contains 1 OPR domain.,similarity:Contains 1 UBA domain.,similarity:Contains 1 ZZ-type zinc finger.,subunit:Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN and RNF29.,

 

Research Area

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